| 本帖最后由 spotlight 于 2022-7-8 09:21 编辑
路透社7月7日报到 https://www.reuters.com/world/us/omicron-sub-variants-ba4-ba5-make-up-70-covid-variants-us-cdc-2022-07-05/
July 5 (Reuters) – The fast-spreading BA.4 and BA.5 sub-lineages of Omicron are estimated to make up a combined 70.1% of the coronavirus variants in the United States as of July 2, the U.S. Centers for Disease Control and Prevention said on Tuesday.
BA.4 and BA.5 made up 52% of U.S. variants for the week of June 25.
6月25日占美国变种得52%，7月2日上升至70.1% — 数据来源：美国CDC
纽约时报6月28日报道 https://www.nytimes.com/2022/06/28/health/covid-subvariants-ba4-ba5.html
“But in my mind, 250 deaths a day is still too many,” Dr. Rochelle Walensky, the C.D.C. director, said last week in Aspen, Colo. “The deaths that we’re seeing are generally among people who are either elderly, frail, many comorbidities who’ve had a lot of vaccine shots, or people who are unvaccinated.”l
“但是在我看来，每天250人死亡仍然太多了，” C.D.C. Rochelle Walensky博士董事上周在科罗拉多州阿斯彭说：“我们所看到的死亡通常是老年人，脆弱的人，许多合并症的人有很多疫苗，或者未接种疫苗的人。”
CNN 6月22日报道 https://edition.cnn.com/2022/06/22/health/ba4-ba5-escape-antibodies-covid-vaccine/index.html
Omicron subvariants BA.4 and BA.5 appear to escape antibody responses among both people who had previous Covid-19 infection and those who have been fully vaccinated and boosted, according to new data from researchers at Beth Israel Deaconess Medical Center, of Harvard Medical School.
However, Covid-19 vaccination is still expected to provide substantial protection against severe disease, and vaccine makers are working on updated shots that might elicit a stronger immune response against the variants.
The levels of neutralizing antibodies that a previous infection or vaccinations elicit are several times lower against the BA.4 and BA.5 subvariants compared with the original coronavirus, according to the new research published in the New England Journal of Medicine on Wednesday.
根据贝丝·伊斯雷尔·伊斯雷尔（Beth Israel Deaconess）医疗中心的研究人员的新数据，Omicron子变量BA.4和BA.5似乎逃脱了以前患有COVID-19感染的人中的抗体反应以及已完全接种和加强针的抗体反应。
但是，COVID-19疫苗仍然有望提供对重症患者的实质性保护，并且疫苗制造商正在研究更新的疫苗，这可能会引起对这种变体的更强烈的免疫反应。
根据新英格兰医学杂志上发表的新研究，与原始冠状病毒相比，对先前的感染或疫苗接种对BA.4和BA.5子变量的中和抗体的水平低几倍。
NBC 7月8日报道 https://www.nbcnews.com/health/health-news/omicron-ba5-ba4-covid-symptoms-vaccines-rcna36894
BA.5, now dominant U.S. variant, may pose the biggest threat to immune protection yet
Pfizer has told NBC News that it could have an updated vaccine targeting BA.4 and BA.5 ready to be distributed in October.
Balloux added, though, that "BA.2, BA.4 and B.5 from a neutralizing antibody perspective are essentially interchangeable." That might mean that people who got BA.2 infections have some protection now.
Montefiori said BA.4 and BA.5 also haven’t been found to cause more severe disease.
"There’s really no clear evidence that they’re more or less likely to make people sick and cause severe illness and death," he said.
Rather, rises in cases and hospitalizations observed in some places more likely have to do with fading vaccine protection.
"We have waning immunity now in the people who got boosted half a year or more ago," Montefiori said.
BA.5，现在是美国的主要变体，可能对迄今为止免疫保护构成最大的威胁
辉瑞（Pfizer）告诉NBC News，它可能有针对BA.4和BA.5的更新疫苗，准备在10月分发。
Balloux补充说，从中和抗体的角度来看，“ BA.2，BA.4和B.5基本上是可以互换的”。这可能意味着获得BA.2感染的人现在有所保护。
蒙特菲奥利说，BA.4和BA.5也没有发现更严重的疾病。
他说：“确实没有明确的证据表明，他们或多或少会使人们生病并造成严重的疾病和死亡。”
相反，在某些地方观察到的病例和住院治疗的情况更可能与疫苗接种太久，保护减弱有关。
蒙特菲奥里说：“我们现在在半年或更长时间前受到接种的人的免疫力减弱。” |
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